Donisthorpe, historically belonging to the Repton and Gresley Hundred of Derbyshire, comes from the Norman male personal name Durand (Middle English genitive singular Durandes) and the Old Norse element þorp ‘outlying farm, settlement’.

Place-names containing þorp are thought to be later names, or at least rather longer lived, than those containing the Old Norse element by ‘farm, settlement’ because there are more instances of post-Conquest-type elements combined with þorp than by. Donisthorpe is an example of one of these place-names. 

Donisthorpe is a joint parish with Oakthorpe and they were both transferred to Leicestershire in 1897. These place-names are close in proximity to Boothorpe and Osgathorpe in Leicestershire demonstrating the density of the Old Norse element þorp across the medieval and modern landscape.